2024
Kwon W, Choi DJ, Yu K, Williamson MR, Murali S, Ko Y, Woo J, Deneen B. Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions. Int J Mol Sci. 2024 Jan 13;25(2):1021. doi: 10.3390/ijms25021021. PMID: 38256095; PMCID: PMC10816327
2023
Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jun 28. doi: 10.1038/s41586-023-06267-2. Epub ahead of print. PMID: 37380778.
Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B. Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 Jun 16;380(6650):eade0027. doi: 10.1126/science.ade0027. Epub 2023 Jun 16. PMID: 37319217.
Choi DJ, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM, Chen HC, Gibbs RA, Ostrom QT, Melin B, Deneen B, Bondy ML; Gliogene Consortium; Genomics England Research Consortium; Bainbridge MN, Amos CI, Barnholtz-Sloan JS, Bernstein JL, Claus EB, Houlston RS, Il'yasova D, Jenkins RB, Johansen C, Lachance D, Lai R, Melin BS, Merrell RT, Olson SH, Sadetzki S, Schildkraut J, Shete S, Ambrose JC, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred CR, Brittain H, Brown MA, Caulfield MJ, Chan GC, Giess A, Griffin JN, Hamblin A, Henderson S, Hubbard TJP, Jackson R, Jones LJ, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Lakey A, Leigh SEA, Leong IUS, Lopez FJ, Maleady-Crowe F, McEntagart M, Minneci F, Mitchell J, Moutsianas L, Mueller M, Murugaesu N, Need AC, O'Donovan P, Odhams CA, Patch C, Perez-Gil D, Pereira MB, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott RH, Siddiq A, Sieghart A, Smith SC, Sosinsky A, Stuckey A, Tanguy M, Taylor Tavares AL, Thomas ERA, Thompson SR, Tucci A, Welland MJ, Williams E, Witkowska K, Wood SM, Zarowiecki M. The genomic landscape of familial glioma. Sci Adv. 2023 Apr 28;9(17):eade2675. doi: 10.1126/sciadv.ade2675. Epub 2023 Apr 28. PMID: 37115922; PMCID: PMC10146888.
Cheng YT, Luna-Figueroa E, Woo J, Chen HC, Lee ZF, Harmanci AS, Deneen B. Inhibitory input directs astrocyte morphogenesis through glial GABABR. Nature. 2023 Apr 26. doi: 10.1038/s41586-023-06010-x. Epub ahead of print. PMID: 37100909.[pub]
Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, Jalali A, Gavvala J, Mohila C, Serin Harmanci A, Noebels J, Rao G, Deneen B. Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron. 2023 Mar 1;111(5):682-695.e9. doi: 10.1016/j.neuron.2023.01.013. Epub 2023 Feb 13. PMID: 36787748; PMCID: PMC9991983. [pub]
Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel B, Maze I, Deneen B. Activity-dependent induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. bioRxiv [Preprint]. 2023 Feb 27:2023.02.24.529904. doi: 10.1101/2023.02.24.529904. PMID: 36909526; PMCID: PMC10002681. [pub]
Cheng YT, Woo J, Luna-Figueroa E, Maleki E, Harmanci AS, Deneen B. Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits. Neuron. 2023 Feb 7:S0896-6273(23)00039-9. doi: 10.1016/j.neuron.2023.01.015. Epub ahead of print. PMID: 36787749. [pub]
2022
Yu K, Kong K, Lozzi B, Luna-Figueroa E, Cervantes A, Curry R, Mohila CA, Rao G, Jalali A, Mills GB, Scott KL, Deneen B. In Vivo Functional Characterization of EGFR Variants Identifies Novel Drivers of Glioblastoma. Neuro Oncol. 2022 Aug 31:noac215. doi: 10.1093/neuonc/noac215. Epub ahead of print. PMID: 36044040. [pub]
Sardar D, Chen HC, Reyes A, Varadharajan S, Jain A, Mohila C, Curry R, Lozzi B, Rajendran K, Cervantes A, Yu K, Jalali A, Rao G, Mack SC, Deneen B. Sox9 directs divergent epigenomic states in brain tumor subtypes. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2202015119. doi: 10.1073/pnas.2202015119. Epub 2022 Jul 15. PMID: 35858326.[pub]
Cheng YT, Woo J, Deneen B. Sculpting Astrocyte Diversity through Circuits and Transcription. Neuroscientist. 2022 Apr 2:10738584221082620. doi: 10.1177/10738584221082620. Epub ahead of print. PMID: 35373633. [pub]
Akdemir ES, Woo J, Bosquez Huerta NA, Lozzi B, Groves AK, Harmanci AS, Deneen B. Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing. J Neurosci. 2022 Jan 26;42(4):567-580. doi: 10.1523/JNEUROSCI.1392-21.2021. Epub 2021 Dec 6. PMID: 34872929; PMCID: PMC8805626. [pub]
2021
David-Bercholz J, Kuo CT, Deneen B. Astrocyte and Oligodendrocyte Responses From the Subventricular Zone After Injury. Front Cell Neurosci. 2021 Dec 24;15:797553. doi: 10.3389/fncel.2021.797553. PMID: 35002630; PMCID: PMC8740317. [pub]
Ung K, Huang TW, Lozzi B, Woo J, Hanson E, Pekarek B, Tepe B, Sardar D, Cheng YT, Liu G, Deneen B, Arenkiel BR. Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain. Nat Commun. 2021 Sep 1;12(1):5230. doi: 10.1038/s41467-021-25444-3. PMID: 34471129 [pub]
Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B. Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis J Neurosci. 2021 Jul 12:JN-RM-0070-21. doi: 10.1523/JNEUROSCI.0070-21.2021. Online ahead of print. PMID: 34253626 [pub]
Jalali A, Yu K, Beechar V, Bosquez Huerta N, Grichuk A, Mehra D, Lozzi B, Kong K, Scott KL, Rao G, Bainbridge MN, Bondy ML, Deneen B. POT1 regulates proliferation and confers sexual dimorphism in glioma.Cancer Res. 2021 Mar 29:canres.3755.2020. doi: 10.1158/0008-5472.CAN-20-3755. Online ahead of print.PMID: 33782098 [pub]
Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De Leon LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC. ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma Cancer Discov. 2021 Mar 19:candisc.1066.2020. doi: 10.1158/2159-8290.CD-20-1066. Online ahead of print. [pub]
2020
Carlson JC, Cantu-Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. Identification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2020 Dec 23:noaa297. doi: 10.1093/neuonc/noaa297. Online ahead of print. PMID: 33367832 [pub]
Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen B. Parallel astrocyte calcium signaling modulates olfactory bulb responses J Neurosci Res. 2020 May 19. doi: 10.1002/jnr.24634. Online ahead of print. [pub]
Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B. Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. Neuron. 2020 Apr 10:S0896-6273(20)30232-4. doi: 10.1016/j.neuron.2020.03.025. Online ahead of print. [pub]
Akdemir ES, Huang AY, Deneen B. Astrocytogenesis: where, when, and how. F1000Res. 2020 Apr 2;9:F1000 Faculty Rev-233. doi: 10.12688/f1000research.22405.1. eCollection 2020. [pub]
Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. (2020) Apr 6. pii: 133316. doi: 10.1172/JCI133316. [Epub ahead of print] [pub]
Lozzi B, Huang TW, Sardar D, Huang AY, Deneen B. Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain Front Neurosci. (2020) Feb 21;14:61. doi: 10.3389/fnins.2020.00061. eCollection 2020. [pub]
Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen B. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature (2020). https://doi.org/10.1038/s41586-020-1952-2 [Epub ahead of print] [pub]
2019
Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. (2019) Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. The Journal of Clinical Investigation 2019. Sep 9. pii: 127492. doi: 10.1172/JCI127492. [Epub ahead of print] [pub]
Khakh BS, Deneen B. (2019) The Emerging Nature of Astrocyte Diversity. Annu Rev Neurosci. 2019 Jul 8;42:187-207. doi: 10.1146/annurev-neuro-070918-050443 [pub]
Wang CY, Deneen B, Tzeng SF. (2019) BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Glia. 2019 Sep;67(9):1775-1792. doi: 10.1002/glia.23660. Epub 2019 Jun 11. [pub]
Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQ (2019) Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases. eNeuro 2019 Mar-Apr; 6(2): ENEURO.0288-18.2019. [pub]
2018
Laug D, Glasgow SM, Deneen B. (2018) A glial blueprint for gliomagenesis. Nature Reviews Neuroscience 2018 May 18 doi: 10.1038/s41583-018-0014-3. [pub]
Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. (2018) Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun 2018 Feb 20;6(1):12. [pub]
2017
Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B (2017) Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 Oct 20;6. pii: e31926. [pub]
Glasgow SM, Carlson J, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis Y, Lozzi B, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee S-K, Mohila CA, and Deneen B. (2017) Glial specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nature Neuroscience Nat Neurosci. 2017 Nov;20(11):1520-1528. Epub 2017 Sep 11 [pub]
Wang CY, Deneen B, Tzeng SF (2017) MicroRNA-212 inhibits oligodendrocytes during maturation by downregulation of differentiation-associated gene expression. Journal of Neurochemistry 2017 Oct;143(1):112-125 [pub]
Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, and Deneen B. (2017) The Identification of Diverse Astrocyte Populations and their Malignant Analogs. Nature Neuroscience 20(3) 396-405. [pub]
**Highlighted in Editors Choice, Science Translational Medicine
**Preview in Frontiers of Neuroscience
Glasgow SM and Deneen B. (2017) lnc’edin to Myelin. Neuron 93(2):252-254 [pub]
2016
Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, and Deneen B (2016) Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and After Injury. Journal of Neuroscience 36(47):11904-11917. [pub]
2015
Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SF, Mohila CM, and Deneen B. (2015) Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia 63(8): 1320-1329. [pub]
Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SF, and Deneen B. (2015) Daam2-PIP5K is a novel regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron 85(6): 1227-1243. [pub]
**Highlighted in Faculty of 1000
Molofsky AV and Deneen B (2015) Astrocyte Development: A guide for the perplexed. Glia 63(8):1320-9. [pub]
2014
Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR (2014) Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Struct Funct. 221(1):1-20. [pub]
Glasgow S, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila CM, and Deneen B. (2014) Mutual Antagonism Between Sox10 and NFIA Regulates Diversification of Glial Lineages and Glioma Sub-Types. Nature Neuroscience 17(10): 1322-1329. [pub]
Gallo V and Deneen B (2014) Glial development: The crossroads of regeneration and repair in the CNS. Neuron. 83(2): 283-308. [pub]
Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song H-R. (2014) A novel tumor-promoting role for Nuclear Factor I A (NFIA) in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro-Oncology Jan;16(2):191-203. [pub]
2013
Glasgow S, Laug D, Brawley V, Zhang Z, Corder A, Yin Z , Wong STC, Li XN, Foster AE, Ahmed A, and Deneen B. (2013) The miR223-NFIA Axis Regulates Glial Precursor Proliferation and Tumorigenesis in the CNS. Journal of Neuroscience 33(33):13560-13568. [pub]
**Featured in Science “Editors Choice” http://www.sciencemag.org/content/341/6150/1044.4.short
Molofsky A, Glasgow S, Chaboub L, Tsai H-H, Murnen AT, Fancy SF, Yuen T, Mahireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham M. (2013) Expression profiling of putative astrocyte precursors in the developing spinal cord identifies Sox9-Nfe2l1 interactions. Glia 61(9): 1518-1532. [pub]
Chaboub LC and Deneen B (2013) Astrocyte form and function in the developing CNS. Seminars in Pediatric Neurology 20(4): 230-235. [pub]
Lin C-C and Deneen B (2013) Astrocytes: The missing link in neurological disease? Seminars in Pediatric Neurology 20(4): 236–241. [pub]
2012
Kang P, Lee HK, Glasgow S, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, and Deneen B (2012) Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron 74(1):79-94. [pub]
**Highlighted in Faculty of 1000
Lee HK and Deneen B (2012) Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Developmental Cell 22(1):183-196. [pub]
**Highlighted in Faculty of 1000
Fancy SF, Glasgow S, Finley M, Rowitch DH, and Deneen B (2012) Evidence that NFIA inhibits repair after white matter injury. Annals of Neurology 72(2):224-233 [pub]
Molofsky A, Tsai H-H, Krenick R, Ullian E, Deneen B, Richardson WD, Barres BA, and Rowitch DH (2012) Astrocytes and Disease: A Neurodevelopmental Perspective. Genes and Development 26:891-907. [pub]
Chaboub LC and Deneen B (2012) Developmental Origins of Astrocyte Heterogeneity: The final frontier of CNS development. Developmental Neuroscience. 34(5):379-388. [pub]
Before 2010
Song H-R, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Ji L, Gilles FH, Deneen B* and Erdreich-Epstein A* (2010) Nuclear Factor I A is expressed in astrocytomas and is associated with improved progression-free survival. Neuro-Oncology 12(2):122-32. [pub]
*Equal Contribution
Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima K (2009) Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Developmental Cell 16(2):245-55. [pub]
Hochstim CJ, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ (2008) The spinal cord contains positionally distinct astrocyte subtypes whose identities are specified by a homeodomain transcriptional code. Cell 133:510-522 [pub]
Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. (2006) The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 52:953-68. [pub]
Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. (2006) Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci USA 103:1551-6. [pub]
Deneen B, Hamidi H, Denny CT. (2003) Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 63:4268-74. [pub]
Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. (2003) PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 23:3897-908. [pub]
Deneen B, Denny CT. (2001) Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene 20:6731-41. [pub]
Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT. (2001) DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem. 276:41977-84. [pub]
Page SL, McKim KS, Deneen B, Van Hook TL, Hawley RS. (2000) Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Genetics 155:1757-72. [pub]
Sekelsky JJ, McKim KS, Messina L, French RL, Hurley WD, Arbel T, Chin GM, Deneen B, Force SJ, Hari KL, Jang JK, Laurencon AC, Madden LD, Matthies HJ, Milliken DB, Page SL, Ring AD, Wayson SM, Zimmerman CC, Hawley RS. (1999) Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 152:529-42. [pub]